Histone Deacetylase Inhibitory Activity and Antiproliferative Potential of New [6]-Shogaol Derivativ...
Histone Deacetylase Inhibitory Activity and Antiproliferative Potential of New [6]-Shogaol Derivatives
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
Twenty newly synthesized derivatives of [6]-shogaol (
) were tested for inhibitory activity against histone deacetylases. All derivatives showed moderate to good histone deacetylase inhibition at 100 µM with a slightly lower potency than the lead compound. Most potent inhibitors among the derivatives were the pyrazole products,
and
and the...
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Full title
Histone Deacetylase Inhibitory Activity and Antiproliferative Potential of New [6]-Shogaol Derivatives
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TN_cdi_doaj_primary_oai_doaj_org_article_350cf8cd211542be831d2503c15d52bf
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_350cf8cd211542be831d2503c15d52bf
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ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules27103332
