p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell s...
p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival
About this item
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Author / Creator
Deng, Longfei , Yao, Pengbo , Li, Le , Ji, Fansen , Zhao, Shuang , Xu, Chang , Lan, Xun and Jiang, Peng
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Asparagine synthetase (ASNS) catalyses the ATP-dependent conversion of aspartate to asparagine. However, both the regulation and biological functions of asparagine in tumour cells remain largely unknown. Here, we report that p53 suppresses asparagine synthesis through the transcriptional downregulation of ASNS expression and disrupts asparagine-asp...
Alternative Titles
Full title
p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival
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Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_35114a7de3be4c06ae8f90c18be3707c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_35114a7de3be4c06ae8f90c18be3707c
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-15573-6
