Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277
Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
The KCNQ1 ion channel plays critical physiological roles in electrical excitability and K
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recycling in organs including the heart, brain, and gut. Loss of function is relatively common and can cause sudden arrhythmic death, sudden infant death, epilepsy and deafness. Here, we report cryogenic electron microscopic (cryo-EM) structures of
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Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277
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TN_cdi_doaj_primary_oai_doaj_org_article_36808af22e5f44a7951153674f707712
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_36808af22e5f44a7951153674f707712
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-31526-7
