ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarat...
ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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2-oxoglutarate (2-OG or α-ketoglutarate) relates mitochondrial metabolism to cell function by modulating the activity of 2-OG dependent dioxygenases involved in the hypoxia response and DNA/histone modifications. However, metabolic pathways that regulate these oxygen and 2-OG sensitive enzymes remain poorly understood. Here, using CRISPR Cas9 genom...
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Full title
ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
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TN_cdi_doaj_primary_oai_doaj_org_article_368ff8225df849cf9afb4ff9c4c9c5e7
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_368ff8225df849cf9afb4ff9c4c9c5e7
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-17862-6
