Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease
Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease
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Publisher
England: eLife Sciences Publications, Ltd
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Language
English
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Publisher
England: eLife Sciences Publications, Ltd
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Contents
The SARS-CoV-2 main protease (M
or Nsp5) is critical for production of viral proteins during infection and, like many viral proteases, also targets host proteins to subvert their cellular functions. Here, we show that the human tRNA methyltransferase TRMT1 is recognized and cleaved by SARS-CoV-2 M
. TRMT1 installs the
,
-dimethylguanosi...
Alternative Titles
Full title
Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease
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TN_cdi_doaj_primary_oai_doaj_org_article_36c0c446888e4117b2ca3e7a3ca1a2bf
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_36c0c446888e4117b2ca3e7a3ca1a2bf
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.91168
