DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer
DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer
About this item
Full title
Author / Creator
Mamlouk, Soulafa , Childs, Liam Harold , Aust, Daniela , Heim, Daniel , Melching, Friederike , Oliveira, Cristiano , Wolf, Thomas , Durek, Pawel , Schumacher, Dirk , Bläker, Hendrik , von Winterfeld, Moritz , Gastl, Bastian , Möhr, Kerstin , Menne, Andrea , Zeugner, Silke , Redmer, Torben , Lenze, Dido , Tierling, Sascha , Möbs, Markus , Weichert, Wilko , Folprecht, Gunnar , Blanc, Eric , Beule, Dieter , Schäfer, Reinhold , Morkel, Markus , Klauschen, Frederick , Leser, Ulf and Sers, Christine
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Genetic heterogeneity between and within tumours is a major factor determining cancer progression and therapy response. Here we examined DNA sequence and DNA copy-number heterogeneity in colorectal cancer (CRC) by targeted high-depth sequencing of 100 most frequently altered genes. In 97 samples, with primary tumours and matched metastases from 27...
Alternative Titles
Full title
DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer
Authors, Artists and Contributors
Author / Creator
Childs, Liam Harold
Aust, Daniela
Heim, Daniel
Melching, Friederike
Oliveira, Cristiano
Wolf, Thomas
Durek, Pawel
Schumacher, Dirk
Bläker, Hendrik
von Winterfeld, Moritz
Gastl, Bastian
Möhr, Kerstin
Menne, Andrea
Zeugner, Silke
Redmer, Torben
Lenze, Dido
Tierling, Sascha
Möbs, Markus
Weichert, Wilko
Folprecht, Gunnar
Blanc, Eric
Beule, Dieter
Schäfer, Reinhold
Morkel, Markus
Klauschen, Frederick
Leser, Ulf
Sers, Christine
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_377eccf6acfe4e04830ad0acf5e3cb0e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_377eccf6acfe4e04830ad0acf5e3cb0e
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms14093
