Concurrent Activation of Both Survival-Promoting and Death-Inducing Signaling by Chloroquine in Glio...
Concurrent Activation of Both Survival-Promoting and Death-Inducing Signaling by Chloroquine in Glioblastoma Stem Cells: Implications for Potential Risks and Benefits of Using Chloroquine as Radiosensitizer
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Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Lysosomotropic agent chloroquine was shown to sensitize non-stem glioblastoma cells to radiation in vitro with p53-dependent apoptosis implicated as one of the underlying mechanisms. The in vivo outcomes of chloroquine or its effects on glioblastoma stem cells have not been previously addressed. This study undertakes a combinatorial approach encomp...
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Concurrent Activation of Both Survival-Promoting and Death-Inducing Signaling by Chloroquine in Glioblastoma Stem Cells: Implications for Potential Risks and Benefits of Using Chloroquine as Radiosensitizer
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TN_cdi_doaj_primary_oai_doaj_org_article_386ad53bcbfe46bab387cbef13ee2a67
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_386ad53bcbfe46bab387cbef13ee2a67
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ISSN
2073-4409
E-ISSN
2073-4409
DOI
10.3390/cells12091290
