Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity...
Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology
About this item
Full title
Author / Creator
Zhang, Cai , Seo, Joonbae , Murakami, Kazutoshi , Salem, Esam S. B. , Bernhard, Elise , Borra, Vishnupriya J. , Choi, Kwangmin , Yuan, Celvie L. , Chan, Calvin C. , Chen, Xiaoting , Huang, Taosheng , Weirauch, Matthew T. , Divanovic, Senad , Qi, Nathan R. , Thomas, Hala Einakat , Mercer, Carol A. , Siomi, Haruhiko and Nakamura, Takahisa
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
RNA silencing inhibits mRNA translation. While mRNA translation accounts for the majority of cellular energy expenditure, it is unclear if RNA silencing regulates energy homeostasis. Here, we report that hepatic Argonaute 2 (Ago2)-mediated RNA silencing regulates both intrinsic energy production and consumption and disturbs energy metabolism in the...
Alternative Titles
Full title
Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology
Authors, Artists and Contributors
Author / Creator
Seo, Joonbae
Murakami, Kazutoshi
Salem, Esam S. B.
Bernhard, Elise
Borra, Vishnupriya J.
Choi, Kwangmin
Yuan, Celvie L.
Chan, Calvin C.
Chen, Xiaoting
Huang, Taosheng
Weirauch, Matthew T.
Divanovic, Senad
Qi, Nathan R.
Thomas, Hala Einakat
Mercer, Carol A.
Siomi, Haruhiko
Nakamura, Takahisa
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_38c391e9f41444b882b89e0d90e18efc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_38c391e9f41444b882b89e0d90e18efc
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05870-6
