Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity
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Author / Creator
Lv, Dongwen , Pal, Pratik , Liu, Xingui , Jia, Yannan , Thummuri, Dinesh , Zhang, Peiyi , Hu, Wanyi , Pei, Jing , Zhang, Qi , Zhou, Shuo , Khan, Sajid , Zhang, Xuan , Hua, Nan , Yang, Qingping , Arango, Sebastian , Zhang, Weizhou , Nayak, Digant , Olsen, Shaun K. , Weintraub, Susan T. , Hromas, Robert , Konopleva, Marina , Yuan, Yaxia , Zheng, Guangrong and Zhou, Daohong
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
PROteolysis-TArgeting Chimeras (PROTACs) have emerged as an innovative drug development platform. However, most PROTACs have been generated empirically because many determinants of PROTAC specificity and activity remain elusive. Through computational modelling of the entire NEDD8-VHL Cullin RING E3 ubiquitin ligase (CRL
VHL
)/PROTAC/BCL-xL/Ub...
Alternative Titles
Full title
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity
Authors, Artists and Contributors
Author / Creator
Pal, Pratik
Liu, Xingui
Jia, Yannan
Thummuri, Dinesh
Zhang, Peiyi
Hu, Wanyi
Pei, Jing
Zhang, Qi
Zhou, Shuo
Khan, Sajid
Zhang, Xuan
Hua, Nan
Yang, Qingping
Arango, Sebastian
Zhang, Weizhou
Nayak, Digant
Olsen, Shaun K.
Weintraub, Susan T.
Hromas, Robert
Konopleva, Marina
Yuan, Yaxia
Zheng, Guangrong
Zhou, Daohong
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_38d97353bbbf41e4aa6eb4a5907c3bd4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_38d97353bbbf41e4aa6eb4a5907c3bd4
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-27210-x
