Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
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Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
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Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
Multiple sclerosis (MS) is a T cell-mediated autoimmune disease of the central nervous system. Foxp3
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regulatory T (Treg) cells are reduced in frequency and dysfunctional in patients with MS, but the underlying mechanisms of this deficiency are unclear. Here, we show that induction of human IFN-γ
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IL-17A
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Foxp3
+
CD4
+...
Alternative Titles
Full title
Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
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TN_cdi_doaj_primary_oai_doaj_org_article_39030d68cecb4083837a09a44d6cae96
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_39030d68cecb4083837a09a44d6cae96
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02406-2
