A novel retinoic acid receptor-γ agonist antagonizes immune checkpoint resistance in lung cancers by...
A novel retinoic acid receptor-γ agonist antagonizes immune checkpoint resistance in lung cancers by altering the tumor immune microenvironment
About this item
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Author / Creator
Wei, Cheng-Hsin , Huang, Lu , Kreh, Blair , Liu, Xiuxia , Tyutyunyk-Massey, Liliya , Kawakami, Masanori , Chen, Zibo , Shi, Mi , Kozlov, Serguei , Chan, King C. , Andresson, Thorkell , Carrington, Mary , Vuligonda, Vidyasagar , Sanders, Martin E. , Horowitz, Amir , Hwu, Patrick , Peng, Weiyi , Dmitrovsky, Ethan and Liu, Xi
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
All-
trans
-retinoic acid (ATRA), the retinoic acid receptors (RARs) agonist, regulates cell growth, differentiation, immunity, and survival. We report that ATRA-treatment repressed cancer growth in syngeneic immunocompetent, but not immunodeficient mice. The tumor microenvironment was implicated: CD8
+
T cell depletion antagonized ATR...
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Full title
A novel retinoic acid receptor-γ agonist antagonizes immune checkpoint resistance in lung cancers by altering the tumor immune microenvironment
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TN_cdi_doaj_primary_oai_doaj_org_article_3a6d32daebaf4a6c91b60abe62aa93bd
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3a6d32daebaf4a6c91b60abe62aa93bd
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-023-41690-5
