DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
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Author / Creator
Sato, Hiro , Niimi, Atsuko , Yasuhara, Takaaki , Permata, Tiara Bunga Mayang , Hagiwara, Yoshihiko , Isono, Mayu , Nuryadi, Endang , Sekine, Ryota , Oike, Takahiro , Kakoti, Sangeeta , Yoshimoto, Yuya , Held, Kathryn D. , Suzuki, Yoshiyuki , Kono, Koji , Miyagawa, Kiyoshi , Nakano, Takashi and Shibata, Atsushi
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Accumulating evidence suggests that exogenous cellular stress induces PD-L1 upregulation in cancer. A DNA double-strand break (DSB) is the most critical type of genotoxic stress, but the involvement of DSB repair in PD-L1 expression has not been investigated. Here we show that PD-L1 expression in cancer cells is upregulated in response to DSBs. Thi...
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Full title
DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_3aa563dc071243218d3b85fb984faf73
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3aa563dc071243218d3b85fb984faf73
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-01883-9
