The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligom...
The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Aggregation of the 140-residue protein α-synuclein (αSN) is a key factor in the etiology of Parkinson’s disease. Although the intensely anionic C-terminal domain (CTD) of αSN does not form part of the amyloid core region or affect membrane binding ability, truncation or reduction of charges in the CTD promotes fibrillation through as yet unknown me...
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The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization
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TN_cdi_doaj_primary_oai_doaj_org_article_3b30c2233d094c1fb5d89c40c979733a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3b30c2233d094c1fb5d89c40c979733a
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ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-022-03059-8
