The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood f...
The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia
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United States: American Society for Clinical Investigation
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Language
English
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Publisher
United States: American Society for Clinical Investigation
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Pericyte-mediated capillary constriction decreases cerebral blood flow in stroke after an occluded artery is unblocked. The determinants of pericyte tone are poorly understood. We show that a small rise in cytoplasmic Ca2+ concentration ([Ca2+]i) in pericytes activated chloride efflux through the Ca2+-gated anion channel TMEM16A, thus depolarizing...
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Full title
The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia
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TN_cdi_doaj_primary_oai_doaj_org_article_3b8175d888bd4fc4971dd023142139a4
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3b8175d888bd4fc4971dd023142139a4
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ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI154118
