Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of hu...
Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer's disease tau
About this item
Full title
Author / Creator
Brendel, Matthias , Deussing, Maximilian , Blume, Tanja , Kaiser, Lena , Probst, Federico , Overhoff, Felix , Peters, Finn , von Ungern-Sternberg, Barbara , Ryazanov, Sergey , Leonov, Andrei , Griesinger, Christian , Zwergal, Andreas , Levin, Johannes , Bartenstein, Peter , Yakushev, Igor , Cumming, Paul , Boening, Guido , Ziegler, Sibylle , Herms, Jochen , Giese, Armin and Rominger, Axel
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Augmenting the brain clearance of toxic oligomers with small molecule modulators constitutes a promising therapeutic concept against tau deposition. However, there has been no test of this concept in animal models of Alzheimer's disease (AD) with initiation at a late disease stage. Thus, we aimed to investigate the effects of interventional late-st...
Alternative Titles
Full title
Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer's disease tau
Authors, Artists and Contributors
Author / Creator
Deussing, Maximilian
Blume, Tanja
Kaiser, Lena
Probst, Federico
Overhoff, Felix
Peters, Finn
von Ungern-Sternberg, Barbara
Ryazanov, Sergey
Leonov, Andrei
Griesinger, Christian
Zwergal, Andreas
Levin, Johannes
Bartenstein, Peter
Yakushev, Igor
Cumming, Paul
Boening, Guido
Ziegler, Sibylle
Herms, Jochen
Giese, Armin
Rominger, Axel
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_3b973999c8e94cd6996a2a71167a7056
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3b973999c8e94cd6996a2a71167a7056
Other Identifiers
ISSN
1758-9193
E-ISSN
1758-9193
DOI
10.1186/s13195-019-0522-z
