Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
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Stanford Univ., CA (United States) , Vuong, Wayne , Khan, Muhammad Bashir , Fischer, Conrad , Arutyunova, Elena , Lamer, Tess , Shields, Justin , Saffran, Holly A. , McKay, Ryan T. , van Belkum, Marco J. , Joyce, Michael A. , Young, Howard S. , Tyrrell, D. Lorne , Vederas, John C. and Lemieux, M. Joanne
Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
The main protease, M
pro
(or 3CL
pro
) in SARS-CoV-2 is a viable drug target because of its essential role in the cleavage of the virus polypeptide. Feline infectious peritonitis, a fatal coronavirus infection in cats, was successfully treated previously with a prodrug GC376, a dipeptide-based protease inhibitor. Here, we show the prodr...
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Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
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TN_cdi_doaj_primary_oai_doaj_org_article_3c902c5ef40f40398c856f91dffa7d74
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3c902c5ef40f40398c856f91dffa7d74
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-18096-2
