Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruati...
Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Heavy menstrual bleeding (HMB) is common and debilitating, and often requires surgery due to hormonal side effects from medical therapies. Here we show that transient, physiological hypoxia occurs in the menstrual endometrium to stabilise hypoxia inducible factor 1 (HIF-1) and drive repair of the denuded surface. We report that women with HMB have...
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Full title
Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation
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TN_cdi_doaj_primary_oai_doaj_org_article_3d625696cf6342b79ac265446a69ab16
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3d625696cf6342b79ac265446a69ab16
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02375-6
