The HSF1–PARP13–PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis
The HSF1–PARP13–PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Poly(ADP-ribose) polymerase 1 (PARP1) is involved in DNA repair, chromatin structure, and transcription. However, the mechanisms that regulate PARP1 distribution on DNA are poorly understood. Here, we show that heat shock transcription factor 1 (HSF1) recruits PARP1 through the scaffold protein PARP13. In response to DNA damage, activated and auto-...
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The HSF1–PARP13–PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis
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TN_cdi_doaj_primary_oai_doaj_org_article_3d6ffc8f89924108bb617e1a5c7fc6ea
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3d6ffc8f89924108bb617e1a5c7fc6ea
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-01807-7
