Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
About this item
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Author / Creator
Khattar, Ekta , Maung, Kyaw Ze Ya , Chew, Chen Li , Ghosh, Arkasubhra , Mok, Michelle Meng Huang , Lee, Pei , Zhang, Jun , Chor, Wei Hong Jeff , Cildir, Gökhan , Wang, Chelsia Qiuxia , Mohd-Ismail, Nur Khairiah , Chin, Desmond Wai Loon , Lee, Soo Chin , Yang, Henry , Shin, Yong-Jae , Nam, Do-Hyun , Chen, Liming , Kumar, Alan Prem , Deng, Lih Wen , Ikawa, Masahito , Gunaratne, Jayantha , Osato, Motomi and Tergaonkar, Vinay
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Increased levels and non-telomeric roles have been reported for shelterin proteins, including RAP1 in cancers. Herein using Rap1 null mice, we provide the genetic evidence that mammalian Rap1 plays a major role in hematopoietic stem cell survival, oncogenesis and response to chemotherapy. Strikingly, this function of RAP1 is independent of its asso...
Alternative Titles
Full title
Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
Authors, Artists and Contributors
Author / Creator
Maung, Kyaw Ze Ya
Chew, Chen Li
Ghosh, Arkasubhra
Mok, Michelle Meng Huang
Lee, Pei
Zhang, Jun
Chor, Wei Hong Jeff
Cildir, Gökhan
Wang, Chelsia Qiuxia
Mohd-Ismail, Nur Khairiah
Chin, Desmond Wai Loon
Lee, Soo Chin
Yang, Henry
Shin, Yong-Jae
Nam, Do-Hyun
Chen, Liming
Kumar, Alan Prem
Deng, Lih Wen
Ikawa, Masahito
Gunaratne, Jayantha
Osato, Motomi
Tergaonkar, Vinay
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_3e889e3b0c2349c59ada25c89786da9e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3e889e3b0c2349c59ada25c89786da9e
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13082-9
