TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac...
TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging
About this item
Full title
Author / Creator
Lyu, Guoliang , Guan, Yiting , Zhang, Chao , Zong, Le , Sun, Lei , Huang, Xiaoke , Huang, Li , Zhang, Lijun , Tian, Xiao-Li , Zhou, Zhongjun and Tao, Wei
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Cellular senescence is a well-orchestrated programmed process involved in age-related pathologies, tumor suppression and embryonic development. TGF-β/Smad is one of the predominant pathways that regulate damage-induced and developmentally programmed senescence. Here we show that canonical TGF-β signaling promotes senescence via miR-29-induced loss...
Alternative Titles
Full title
TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_3fc4fb45806142b6abbf012e462c3364
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3fc4fb45806142b6abbf012e462c3364
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04994-z
