SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation
SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation
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Author / Creator
Pan, Pan , Shen, Miaomiao , Yu, Zhenyang , Ge, Weiwei , Chen, Keli , Tian, Mingfu , Xiao, Feng , Wang, Zhenwei , Wang, Jun , Jia, Yaling , Wang, Wenbiao , Wan, Pin , Zhang, Jing , Chen, Weijie , Lei, Zhiwei , Chen, Xin , Luo, Zhen , Zhang, Qiwei , Xu, Meng , Li, Geng , Li, Yongkui and Wu, Jianguo
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 infection are also associated with COVID-19 severity. Here, we show a distinct mechanism by which SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammatio...
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Full title
SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation
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TN_cdi_doaj_primary_oai_doaj_org_article_40b9476cf93f4264a3303d60ead8698b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_40b9476cf93f4264a3303d60ead8698b
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-25015-6
