Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and en...
Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Triple-negative breast cancer (BCa) (TNBC) is a deadly form of human BCa with limited treatment options and poor prognosis. In our prior analysis of over 2200 breast cancer samples, the G protein-coupled receptor CCR5 was expressed in > 95% of TNBC samples. A humanized monoclonal antibody to CCR5 (leronlimab), used in the treatment of HIV-infected...
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Full title
Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy
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TN_cdi_doaj_primary_oai_doaj_org_article_41566b0001e24966bb1515ddc84ff1a7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_41566b0001e24966bb1515ddc84ff1a7
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ISSN
1465-542X,1465-5411
E-ISSN
1465-542X
DOI
10.1186/s13058-021-01391-1
