In vivo base editing of post-mitotic sensory cells
In vivo base editing of post-mitotic sensory cells
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Programmable nucleases can introduce precise changes to genomic DNA through homology-directed repair (HDR). Unfortunately, HDR is largely restricted to mitotic cells, and is typically accompanied by an excess of stochastic insertions and deletions (indels). Here we present an in vivo base editing strategy that addresses these limitations. We use nu...
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In vivo base editing of post-mitotic sensory cells
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TN_cdi_doaj_primary_oai_doaj_org_article_425b7eebb92745d5aeb9260de20796e0
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_425b7eebb92745d5aeb9260de20796e0
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04580-3
