Hypoxia induces ROS-resistant memory upon reoxygenation in vivo promoting metastasis in part via MUC...
Hypoxia induces ROS-resistant memory upon reoxygenation in vivo promoting metastasis in part via MUC1-C
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Author / Creator
Godet, Inês , Oza, Harsh H. , Shi, Yi , Joe, Natalie S. , Weinstein, Alyssa G. , Johnson, Jeanette , Considine, Michael , Talluri, Swathi , Zhang, Jingyuan , Xu, Reid , Doctorman, Steven , Mbulaiteye, Delma , Stein-O’Brien, Genevieve , Kagohara, Luciane T. , Santa-Maria, Cesar A. , Fertig, Elana J. and Gilkes, Daniele M.
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Hypoxia occurs in 90% of solid tumors and is associated with metastasis and mortality. Breast cancer cells that experience intratumoral hypoxia are 5x more likely to develop lung metastasis in animal models. Using spatial transcriptomics, we determine that hypoxic cells localized in more oxygenated tumor regions (termed ‘post-hypoxic’) retain expre...
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Full title
Hypoxia induces ROS-resistant memory upon reoxygenation in vivo promoting metastasis in part via MUC1-C
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TN_cdi_doaj_primary_oai_doaj_org_article_426e0d8a44dd43e7bc5d581380aed53f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_426e0d8a44dd43e7bc5d581380aed53f
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-51995-2
