NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose meta...
NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation
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London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Loss-of-function mutations in
NEK1
gene, which encodes a serine/threonine kinase, are involved in human developmental disorders and ALS. Here we show that NEK1 regulates retromer-mediated endosomal trafficking by phosphorylating VPS26B. NEK1 deficiency disrupts endosomal trafficking of plasma membrane proteins and cerebral proteome homeostasi...
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NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation
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TN_cdi_doaj_primary_oai_doaj_org_article_4294aac17a8b4f399739cdbf82ea2a17
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4294aac17a8b4f399739cdbf82ea2a17
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-25157-7
