Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction
Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Mitochondrial diseases impair oxidative phosphorylation and ATP production, while effective treatment is still lacking. Defective complex III is associated with a highly variable clinical spectrum. We show that pyocyanin, a bacterial redox cycler, can replace the redox functions of complex III, acting as an electron shunt. Sub-μM pyocyanin was harm...
Alternative Titles
Full title
Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_43a9b3426f6b484aad43fa64d8021ac2
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_43a9b3426f6b484aad43fa64d8021ac2
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-22062-x
