Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau
Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Mice transgenic for human mutant P301S tau are widely used as models for human tauopathies. They develop neurodegeneration and abundant filamentous inclusions made of human mutant four-repeat tau. Here we used electron cryo-microscopy (cryo-EM) to determine the structures of tau filaments from the brains of Tg2541 and PS19 mice. Both lines express...
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Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau
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TN_cdi_doaj_primary_oai_doaj_org_article_43edd87f5ecc46a6b3d9100ebbe7d73f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_43edd87f5ecc46a6b3d9100ebbe7d73f
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ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-023-01658-y
