An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated re...
An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress
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Author / Creator
Igarashi, Taichi , Mazevet, Marianne , Yasuhara, Takaaki , Yano, Kimiyoshi , Mochizuki, Akifumi , Nishino, Makoto , Yoshida, Tatsuya , Yoshida, Yukihiro , Takamatsu, Nobuhiko , Yoshimi, Akihide , Shiraishi, Kouya , Horinouchi, Hidehito , Kohno, Takashi , Hamamoto, Ryuji , Adachi, Jun , Zou, Lee and Shiotani, Bunsyo
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Activation of the
KRAS
oncogene is a source of replication stress, but how this stress is generated and how it is tolerated by cancer cells remain poorly understood. Here we show that induction of KRAS
G12V
expression in untransformed cells triggers H3K27me3 and HP1-associated chromatin compaction in an RNA transcription dependent manne...
Alternative Titles
Full title
An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress
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TN_cdi_doaj_primary_oai_doaj_org_article_43f90e5e10dd446096f58be5f96dcc74
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_43f90e5e10dd446096f58be5f96dcc74
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-40578-2