Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reini...
Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation
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Publisher
England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Gene disruption in mouse embryonic stem cells or zygotes is a conventional genetics approach to identify gene function in vivo. However, because different gene disruption strategies use different mechanisms to disrupt genes, the strategies can result in diverse phenotypes in the resulting mouse model. To determine whether different gene disruption...
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Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation
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TN_cdi_doaj_primary_oai_doaj_org_article_4542729f114f4a1997e48e7b8d00f056
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4542729f114f4a1997e48e7b8d00f056
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ISSN
1474-760X,1474-7596
E-ISSN
1474-760X
DOI
10.1186/s13059-020-02086-0
