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154 results for Shultz,+Leonard+D.

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ArticlesPeer ReviewedFull Text
Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status
Author / Creator:Li, Peishan ; Lu, Ming ; Shi, Jiayuan ; Hua, Li ; Gong, Zheng ; Li, Qing ; Shultz, Leonard D. ; Ren, Guangwen
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-09, Vol.11 (1), p.1-14, Article 4387
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Humanized mice in translational biomedical research
Author / Creator:Shultz, Leonard D. ; Ishikawa, Fumihiko ; Greiner, Dale L.
Publisher:London: Nature Publishing Group UK
Journal title:Nature Reviews: Immunology, 2007-02, Vol.7 (2), p.118-130
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AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphy...
Author / Creator:Youngblood, Bradford A. ; Brock, Emily C. ; Leung, John ; Falahati, Rustom ; Bryce, Paul J. ; Bright, Jessica ; Williams, Jason ; Shultz, Leonard D. ; Greiner, Dale L. ; Brehm, Michael A. ; Bebbington, Christopher ; Tomasevic, Nenad
Publisher:Basel, Switzerland: S. Karger AG
Journal title:International archives of allergy and immunology, 2019-09, Vol.180 (2), p.91-102
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Overcoming Current Limitations in Humanized Mouse Research
Author / Creator:Brehm, Michael A. ; Shultz, Leonard D. ; Luban, Jeremy ; Greiner, Dale L.
Publisher:Oxford: Oxford University Press
Journal title:The Journal of infectious diseases, 2013-11, Vol.208 (suppl_2), p.S125-S130
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Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection
Author / Creator:Sewald, Xaver ; Ladinsky, Mark S. ; Uchil, Pradeep D. ; Beloor, Jagadish ; Pi, Ruoxi ; Herrmann, Christin ; Motamedi, Nasim ; Murrooka, Thomas T. ; Brehm, Michael A. ; Greiner, Dale L. ; Shultz, Leonard D. ; Mempel, Thorsten R. ; Bjorkman, Pamela J. ; Kumar, Priti ; Mothes, Walther
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2015-10, Vol.350 (6260), p.563-567
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Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML
Author / Creator:Saito, Yoriko ; Uchida, Naoyuki ; Tanaka, Satoshi ; Suzuki, Nahoko ; Tomizawa-Murasawa, Mariko ; Sone, Akiko ; Najima, Yuho ; Takagi, Shinsuke ; Aoki, Yuki ; Wake, Atsushi ; Taniguchi, Shuichi ; Shultz, Leonard D ; Ishikawa, Fumihiko
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2010-03, Vol.28 (3), p.275-280
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Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation
Author / Creator:Hosur, Vishnu ; Low, Benjamin E. ; Li, Daniel ; Stafford, Grace A. ; Kohar, Vivek ; Shultz, Leonard D. ; Wiles, Michael V.
Publisher:England: BioMed Central Ltd
Journal title:Genome Biology, 2020-07, Vol.21 (1), p.168-168, Article 168
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Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region
Author / Creator:Ishikawa, Fumihiko ; Yoshida, Shuro ; Saito, Yoriko ; Hijikata, Atsushi ; Kitamura, Hiroshi ; Tanaka, Satoshi ; Nakamura, Ryu ; Tanaka, Toru ; Tomiyama, Hiroko ; Saito, Noriyuki ; Fukata, Mitsuhiro ; Miyamoto, Toshihiro ; Lyons, Bonnie ; Ohshima, Koichi ; Uchida, Naoyuki ; Taniguchi, Shuichi ; Ohara, Osamu ; Akashi, Koichi ; Harada, Mine ; Shultz, Leonard D
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2007-11, Vol.25 (11), p.1315-1321
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ArticlesPeer ReviewedFull Text
Stress-impaired transcription factor expression and insulin secretion in transplanted human islets
Author / Creator:Dai, Chunhua ; Kayton, Nora S. ; Shostak, Alena ; Poffenberger, Greg ; Cyphert, Holly A. ; Aramandla, Radhika ; Thompson, Courtney ; Papagiannis, Ioannis G. ; Emfinger, Christopher ; Shiota, Masakazu ; Stafford, John M. ; Greiner, Dale L. ; Herrera, Pedro L. ; Shultz, Leonard D. ; Stein, Roland ; Powers, Alvin C.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2016-05, Vol.126 (5), p.1857-1870
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ArticlesPeer ReviewedFull Text
A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours
Author / Creator:Mercado-Lubo, Regino ; Zhang, Yuanwei ; Zhao, Liang ; Rossi, Kyle ; Wu, Xiang ; Zou, Yekui ; Castillo, Antonio ; Leonard, Jack ; Bortell, Rita ; Greiner, Dale L. ; Shultz, Leonard D. ; Han, Gang ; McCormick, Beth A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-07, Vol.7 (1), p.12225-12225, Article 12225
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ArticlesPeer ReviewedFull Text
A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation
Author / Creator:Zhao, Lihong ; Spassieva, Stefka D. ; Jucius, Thomas J. ; Shultz, Leonard D. ; Shick, H. Elizabeth ; Macklin, Wendy B. ; Hannun, Yusuf A. ; Obeid, Lina M. ; Ackerman, Susan L.
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2011-05, Vol.7 (5), p.e1002063-e1002063
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ArticlesPeer ReviewedFull Text
Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells
Author / Creator:Wagenblast, Elvin ; Azkanaz, Maria ; Smith, Sabrina A. ; Shakib, Lorien ; McLeod, Jessica L. ; Krivdova, Gabriela ; Araújo, Joana ; Shultz, Leonard D. ; Gan, Olga I. ; Dick, John E. ; Lechman, Eric R.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-10, Vol.10 (1), p.4730-11, Article 4730
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ArticlesPeer ReviewedFull Text
Humanized Mouse Model of Ovarian Cancer Recapitulates Patient Solid Tumor Progression, Ascites Formation, and Metastasis
Author / Creator:Bankert, Richard B. ; Balu-Iyer, Sathy V. ; Odunsi, Kunle ; Shultz, Leonard D. ; Kelleher, Raymond J. ; Barnas, Jennifer L. ; Simpson-Abelson, Michelle ; Parsons, Robert ; Yokota, Sandra J.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2011-09, Vol.6 (9), p.e24420-e24420
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Humanized immune system mouse models: progress, challenges and opportunities
Author / Creator:Allen, Todd M. ; Brehm, Michael A. ; Bridges, Sandra ; Ferguson, Stacy ; Kumar, Priti ; Mirochnitchenko, Oleg ; Palucka, Karolina ; Pelanda, Roberta ; Sanders-Beer, Brigitte ; Shultz, Leonard D. ; Su, Lishan ; PrabhuDas, Mercy
Publisher:United States
Journal title:Nature immunology, 2019-07, Vol.20 (7), p.770-774
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ArticlesPeer ReviewedFull Text
Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin
Author / Creator:Hosur, Vishnu ; Johnson, Kenneth R. ; Burzenski, Lisa M. ; Stearns, Timothy M. ; Maser, Richard S. ; Shultz, Leonard D.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-05, Vol.111 (21), p.E2200-E2209
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GLI1 regulates a novel neuropilin‐2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation
Author / Creator:Goel, Hira Lal ; Pursell, Bryan ; Chang, Cheng ; Shaw, Leslie M. ; Mao, Junhao ; Simin, Karl ; Kumar, Prashant ; Kooi, Craig W. Vander ; Shultz, Leonard D. ; Greiner, Dale L. ; Norum, Jens Henrik ; Toftgard, Rune ; Kuperwasser, Charlotte ; Mercurio, Arthur M.
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2013-04, Vol.5 (4), p.488-508
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Inactive rhomboid proteins RHBDF1 and RHBDF2 (iRhoms): a decade of research in murine models
Author / Creator:Burzenski, Lisa M. ; Low, Benjamin E. ; Kohar, Vivek ; Shultz, Leonard D. ; Wiles, Michael V. ; Hosur, Vishnu
Publisher:New York: Springer US
Journal title:Mammalian genome, 2021-12, Vol.32 (6), p.415-426
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Circulating CD34+ cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice
Author / Creator:Saito, Noriyuki ; Yamauchi, Takuji ; Kawano, Noriaki ; Ono, Rintaro ; Yoshida, Shuro ; Miyamoto, Toshihiro ; Kamimura, Tomohiko ; Shultz, Leonard D. ; Saito, Yoriko ; Takenaka, Katsuto ; Shimoda, Kazuya ; Harada, Mine ; Akashi, Koichi ; Ishikawa, Fumihiko
Publisher:Singapore: Springer Singapore
Journal title:International journal of hematology, 2022-02, Vol.115 (2), p.198-207
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Dapagliflozin Does Not Directly Affect Human α or β Cells
Author / Creator:Dai, Chunhua ; Walker, John T ; Shostak, Alena ; Bouchi, Yasir ; Poffenberger, Greg ; Hart, Nathaniel J ; Jacobson, David A ; Calcutt, M Wade ; Bottino, Rita ; Greiner, Dale L ; Shultz, Leonard D ; McGuinness, Owen P ; Dean, E Danielle ; Powers, Alvin C
Publisher:US: Oxford University Press
Journal title:Endocrinology (Philadelphia), 2020-08, Vol.161 (8)
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ArticlesPeer ReviewedFull Text
Chronic Proliferative Dermatitis in Sharpin Null Mice: Development of an Autoinflammatory Disease in the Absence of B and T Lymphocytes and IL4/IL13 Signaling
Author / Creator:Potter, Christopher S. ; Wang, Zhe ; Silva, Kathleen A. ; Kennedy, Victoria E. ; Stearns, Timothy M. ; Burzenski, Lisa ; Shultz, Leonard D. ; HogenEsch, Harm ; Sundberg, John P.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-01, Vol.9 (1), p.e85666
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Showing 1 to 20 of 154 results

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Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status

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Humanized mice in translational biomedical research

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AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphy...

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Overcoming Current Limitations in Humanized Mouse Research

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Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection

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Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML

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Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation

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Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region

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Stress-impaired transcription factor expression and insulin secretion in transplanted human islets

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A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours

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A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation

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Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells

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Humanized Mouse Model of Ovarian Cancer Recapitulates Patient Solid Tumor Progression, Ascites Formation, and Metastasis

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Humanized immune system mouse models: progress, challenges and opportunities

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Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin

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GLI1 regulates a novel neuropilin‐2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation

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Inactive rhomboid proteins RHBDF1 and RHBDF2 (iRhoms): a decade of research in murine models

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Circulating CD34+ cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice

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Dapagliflozin Does Not Directly Affect Human α or β Cells

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Chronic Proliferative Dermatitis in Sharpin Null Mice: Development of an Autoinflammatory Disease in the Absence of B and T Lymphocytes and IL4/IL13 Signaling

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