IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro
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Author / Creator
Prelli Bozzo, Caterina , Nchioua, Rayhane , Volcic, Meta , Koepke, Lennart , Krüger, Jana , Schütz, Desiree , Heller, Sandra , Stürzel, Christina M. , Kmiec, Dorota , Conzelmann, Carina , Müller, Janis , Zech, Fabian , Braun, Elisabeth , Groß, Rüdiger , Wettstein, Lukas , Weil, Tatjana , Weiß, Johanna , Diofano, Federica , Rodríguez Alfonso, Armando A. , Wiese, Sebastian , Sauter, Daniel , Münch, Jan , Goffinet, Christine , Catanese, Alberto , Schön, Michael , Boeckers, Tobias M. , Stenger, Steffen , Sato, Kei , Just, Steffen , Kleger, Alexander , Sparrer, Konstantin M. J. and Kirchhoff, Frank
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) can restrict viral pathogens, but pro- and anti-viral activities have been reported for coronaviruses. Here, we show that artificial overexpression of IFITMs blocks SARS-CoV-2 infection. However, endogenous IFITM expression supports efficient infection of SARS-CoV-2 in human lung cells....
Alternative Titles
Full title
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro
Authors, Artists and Contributors
Author / Creator
Nchioua, Rayhane
Volcic, Meta
Koepke, Lennart
Krüger, Jana
Schütz, Desiree
Heller, Sandra
Stürzel, Christina M.
Kmiec, Dorota
Conzelmann, Carina
Müller, Janis
Zech, Fabian
Braun, Elisabeth
Groß, Rüdiger
Wettstein, Lukas
Weil, Tatjana
Weiß, Johanna
Diofano, Federica
Rodríguez Alfonso, Armando A.
Wiese, Sebastian
Sauter, Daniel
Münch, Jan
Goffinet, Christine
Catanese, Alberto
Schön, Michael
Boeckers, Tobias M.
Stenger, Steffen
Sato, Kei
Just, Steffen
Kleger, Alexander
Sparrer, Konstantin M. J.
Kirchhoff, Frank
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_45486c77950d4620853ea7ad4237e600
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_45486c77950d4620853ea7ad4237e600
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-24817-y
