Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
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Author / Creator
Wang, Bei , Wu, Lujin , Chen, Jing , Dong, Lingli , Chen, Chen , Wen, Zheng , Hu, Jiong , Fleming, Ingrid and Wang, Dao Wen
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology, carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified AA on the inner surface of the cell membrane is hydrolyzed to its free form by phospholipase A2 (PLA2), which is in turn further metabolized by cyclooxygenases (COXs) and lipoxygena...
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Full title
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
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TN_cdi_doaj_primary_oai_doaj_org_article_46018f62e17246b7b4a09effe2eea464
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_46018f62e17246b7b4a09effe2eea464
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ISSN
2059-3635,2095-9907
E-ISSN
2059-3635
DOI
10.1038/s41392-020-00443-w