PMCA-generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion...
PMCA-generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion disease in mice
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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Fatal Familial Insomnia (FFI) is a genetic prion disease caused by the D178N mutation in the prion protein gene (PRNP) in coupling phase with methionine at PRNP 129. In 2017, we have shown that the olfactory mucosa (OM) collected from FFI patients contained traces of PrPSc detectable by Protein Misfolding Cyclic Amplification (PMCA).
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PMCA-generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion disease in mice
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TN_cdi_doaj_primary_oai_doaj_org_article_4644b327b7314f66a695129f90b90075
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4644b327b7314f66a695129f90b90075
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.65311
