G2 checkpoint targeting via Wee1 inhibition radiosensitizes EGFRvIII-positive glioblastoma cells
G2 checkpoint targeting via Wee1 inhibition radiosensitizes EGFRvIII-positive glioblastoma cells
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England: BioMed Central Ltd
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Language
English
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England: BioMed Central Ltd
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The gene of the Epidermal growth factor receptor (EGFR) is one of the most frequently altered genes in glioblastoma (GBM), with deletions of exons 2-7 (EGFRvIII) being amongst the most common genomic mutations. EGFRvIII is heterogeneously expressed in GBM. We already showed that EGFRvIII expression has an impact on chemosensitivity, replication str...
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G2 checkpoint targeting via Wee1 inhibition radiosensitizes EGFRvIII-positive glioblastoma cells
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TN_cdi_doaj_primary_oai_doaj_org_article_465e6b79a1ff4eba9893278ef9efb89a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_465e6b79a1ff4eba9893278ef9efb89a
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ISSN
1748-717X
E-ISSN
1748-717X
DOI
10.1186/s13014-023-02210-x
