RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors
RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
CRISPR-Cas9 transcriptional repressors have emerged as robust tools for disrupting gene regulation in vitro but have not yet been adapted for systemic delivery in adult animal models. Here we describe a
Staphylococcus aureus
Cas9-based repressor (dSaCas9
KRAB
) compatible with adeno-associated viral (AAV) delivery. To evaluate dSaCas9
Alternative Titles
Full title
RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors
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TN_cdi_doaj_primary_oai_doaj_org_article_46f1559feeb54a51902bab3a11b455bc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_46f1559feeb54a51902bab3a11b455bc
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04048-4
