Cytosine base editors induce off-target mutations and adverse phenotypic effects in transgenic mice
Cytosine base editors induce off-target mutations and adverse phenotypic effects in transgenic mice
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Author / Creator
Yan, Nana , Feng, Hu , Sun, Yongsen , Xin, Ying , Zhang, Haihang , Lu, Hongjiang , Zheng, Jitan , He, Chenfei , Zuo, Zhenrui , Yuan, Tanglong , Li, Nana , Xie, Long , Wei, Wu , Sun, Yidi and Zuo, Erwei
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Base editors have been reported to induce off-target mutations in cultured cells, mouse embryos and rice, but their long-term effects in vivo remain unknown. Here, we develop a Systematic evaluation Approach For gene Editing tools by Transgenic mIce (SAFETI), and evaluate the off-target effects of BE3, high fidelity version of CBE (YE1-BE3-FNLS) an...
Alternative Titles
Full title
Cytosine base editors induce off-target mutations and adverse phenotypic effects in transgenic mice
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TN_cdi_doaj_primary_oai_doaj_org_article_471d0bf5b95947c2934db09d1720ed32
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_471d0bf5b95947c2934db09d1720ed32
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-37508-7
