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ArticlesPeer ReviewedFull Text
Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos
Author / Creator:Zuo, Erwei ; Sun, Yidi ; Wei, Wu ; Yuan, Tanglong ; Ying, Wenqin ; Sun, Hao ; Yuan, Liyun ; Steinmetz, Lars M. ; Li, Yixue ; Yang, Hui
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2019-04, Vol.364 (6437), p.289-292
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ArticlesPeer ReviewedFull Text
A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects
Author / Creator:Zuo, Erwei ; Sun, Yidi ; Yuan, Tanglong ; He, Bingbing ; Zhou, Changyang ; Ying, Wenqin ; Liu, Jing ; Wei, Wu ; Zeng, Rong ; Li, Yixue ; Yang, Hui
Publisher:New York: Nature Publishing Group US
Journal title:Nature methods, 2020-06, Vol.17 (6), p.600-604
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ArticlesPeer ReviewedFull Text
Optimization of C-to-G base editors with sequence context preference predictable by machine learning methods
Author / Creator:Yuan, Tanglong ; Yan, Nana ; Fei, Tianyi ; Zheng, Jitan ; Meng, Juan ; Li, Nana ; Liu, Jing ; Zhang, Haihang ; Xie, Long ; Ying, Wenqin ; Li, Di ; Shi, Lei ; Sun, Yongsen ; Li, Yongyao ; Li, Yixue ; Sun, Yidi ; Zuo, Erwei
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-08, Vol.12 (1), p.4902-11, Article 4902
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ArticlesPeer ReviewedFull Text
Adenine base editors induce off-target structure variations in mouse embryos and primary human T cells
Author / Creator:Wu, Leilei ; Jiang, Shutan ; Shi, Meisong ; Yuan, Tanglong ; Li, Yaqin ; Huang, Pinzheng ; Li, Yingqi ; Zuo, Erwei ; Zhou, Changyang ; Sun, Yidi
Publisher:England: BioMed Central Ltd
Journal title:Genome Biology, 2024-11, Vol.25 (1), p.291-291, Article 291
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ArticlesPeer ReviewedFull Text
GOTI, a method to identify genome-wide off-target effects of genome editing in mouse embryos
Author / Creator:Zuo, Erwei ; Sun, Yidi ; Wei, Wu ; Yuan, Tanglong ; Ying, Wenqin ; Sun, Hao ; Yuan, Liyun ; Steinmetz, Lars M. ; Li, Yixue ; Yang, Hui
Publisher:London: Nature Publishing Group UK
Journal title:Nature protocols, 2020-09, Vol.15 (9), p.3009-3029
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ArticlesPeer ReviewedFull Text
Cytosine base editors induce off-target mutations and adverse phenotypic effects in transgenic mice
Author / Creator:Yan, Nana ; Feng, Hu ; Sun, Yongsen ; Xin, Ying ; Zhang, Haihang ; Lu, Hongjiang ; Zheng, Jitan ; He, Chenfei ; Zuo, Zhenrui ; Yuan, Tanglong ; Li, Nana ; Xie, Long ; Wei, Wu ; Sun, Yidi ; Zuo, Erwei
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-03, Vol.14 (1), p.1784-12, Article 1784
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ArticlesPeer ReviewedFull Text
Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation
Author / Creator:Li, Guoling ; Dong, Xue ; Luo, Jiamin ; Yuan, Tanglong ; Li, Tong ; Zhao, Guoli ; Zhang, Hainan ; Zhou, Jingxing ; Zeng, Zhenhai ; Cui, Shuna ; Wang, Haoqiang ; Wang, Yin ; Yu, Yuyang ; Yuan, Yuan ; Zuo, Erwei ; Xu, Chunlong ; Huang, Jinhai ; Zhou, Yingsi
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-09, Vol.15 (1), p.8090-10, Article 8090
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ArticlesPeer ReviewedFull Text
Undetectable off-target effects induced by FokI catalytic domain in mouse embryos
Author / Creator:Xie, Long ; Feng, Hu ; Li, Zhifang ; Li, Di ; Yang, Xiali ; Yuan, Tanglong ; Yan, Nana ; He, Chenfei ; Zheng, Jitan ; Zuo, Zhenrui ; Zheng, Yaxuan ; Cao, Yaqi ; Lu, Yangqing ; Xiong, Xing Yao ; Zuo, Erwei
Publisher:England: BioMed Central Ltd
Journal title:Genome Biology, 2024-02, Vol.25 (1), p.51-51, Article 51
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ArticlesPeer ReviewedFull Text
Author Correction: Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation
Author / Creator:Li, Guoling ; Dong, Xue ; Luo, Jiamin ; Yuan, Tanglong ; Li, Tong ; Zhao, Guoli ; Zhang, Hainan ; Zhou, Jingxing ; Zeng, Zhenhai ; Cui, Shuna ; Wang, Haoqiang ; Wang, Yin ; Yu, Yuyang ; Yuan, Yuan ; Zuo, Erwei ; Xu, Chunlong ; Huang, Jinhai ; Zhou, Yingsi
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-10, Vol.15 (1), p.9001-1, Article 9001
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ArticlesPeer ReviewedFull Text
Author Correction: Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes
Author / Creator:Xu, Chunlong ; Zhou, Yingsi ; Xiao, Qingquan ; He, Bingbing ; Geng, Guannan ; Wang, Zikang ; Cao, Birong ; Dong, Xue ; Bai, Weiya ; Wang, Yifan ; Wang, Xiang ; Zhou, Dongming ; Yuan, Tanglong ; Huo, Xiaona ; Lai, Jinsheng ; Yang, Hui
Publisher:New York: Nature Publishing Group US
Journal title:Nature methods, 2022-02, Vol.19 (2), p.255-255
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ArticlesPeer ReviewedFull Text
Deep learning models incorporating endogenous factors beyond DNA sequences improve the prediction accuracy of base editing outcomes
Author / Creator:Yuan, Tanglong ; Wu, Leilei ; Li, Shiyan ; Zheng, Jitan ; Li, Nana ; Xiao, Xiao ; Zhang, Haihang ; Fei, Tianyi ; Xie, Long ; Zuo, Zhenrui ; Li, Di ; Huang, Pinzheng ; Feng, Hu ; Cao, Yaqi ; Yan, Nana ; Wei, Xinming ; Shi, Lei ; Sun, Yongsen ; Wei, Wu ; Sun, Yidi ; Zuo, Erwei
Publisher:Singapore: Springer Nature Singapore
Journal title:Cell discovery, 2024-02, Vol.10 (1), p.20-19, Article 20
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ArticlesPeer ReviewedFull Text
Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes
Author / Creator:Xu, Chunlong ; Zhou, Yingsi ; Xiao, Qingquan ; He, Bingbing ; Geng, Guannan ; Wang, Zikang ; Cao, Birong ; Dong, Xue ; Bai, Weiya ; Wang, Yifan ; Wang, Xiang ; Zhou, Dongming ; Yuan, Tanglong ; Huo, Xiaona ; Lai, Jinsheng ; Yang, Hui
Publisher:New York: Nature Publishing Group US
Journal title:Nature methods, 2021-05, Vol.18 (5), p.499-506
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ArticlesFull Text
High-fidelity base editor with no detectable genome-wide off-target effects
Author / Creator:Zuo, Erwei ; Sun, Yidi ; Yuan, Tanglong ; He, Bingbing ; Zhou, Changyang ; Wenqin Ying ; Liu, Jing ; Wu, Wei ; Zeng, Rong ; Li, Yixue ; Yang, Hui
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2020-02
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ArticlesFull Text
Base editing generates substantial off-target single nucleotide variants
Author / Creator:Yang, Hui ; Li, Yixue ; Zuo, Erwei ; Sun, Yidi ; Wu, Wei ; Yuan, Tanglong ; Wenqin Ying ; Steinmetz, Lars M
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2018-11
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Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos

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A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects

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Optimization of C-to-G base editors with sequence context preference predictable by machine learning methods

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Adenine base editors induce off-target structure variations in mouse embryos and primary human T cells

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GOTI, a method to identify genome-wide off-target effects of genome editing in mouse embryos

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Cytosine base editors induce off-target mutations and adverse phenotypic effects in transgenic mice

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Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation

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Undetectable off-target effects induced by FokI catalytic domain in mouse embryos

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Author Correction: Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation

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Author Correction: Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes

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Deep learning models incorporating endogenous factors beyond DNA sequences improve the prediction accuracy of base editing outcomes

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Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes

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High-fidelity base editor with no detectable genome-wide off-target effects

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Base editing generates substantial off-target single nucleotide variants

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