Structure‐based identification of dual ligands at the A2AR and PDE10A with anti‐proliferative effect...
Structure‐based identification of dual ligands at the A2AR and PDE10A with anti‐proliferative effects in lung cancer cell‐lines
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Cham: Springer International Publishing
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English
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Cham: Springer International Publishing
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Enhanced/prolonged cAMP signalling has been suggested as a suppressor of cancer proliferation. Interestingly, two key modulators that elevate cAMP, the A
2A
receptor (A
2A
R) and phosphodiesterase 10A (PDE10A), are differentially co-expressed in various types of non-small lung cancer (NSCLC) cell-lines. Thus, finding dual-target compoun...
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Full title
Structure‐based identification of dual ligands at the A2AR and PDE10A with anti‐proliferative effects in lung cancer cell‐lines
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TN_cdi_doaj_primary_oai_doaj_org_article_475f56f41ee54ebda841325ad9547893
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_475f56f41ee54ebda841325ad9547893
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ISSN
1758-2946
E-ISSN
1758-2946
DOI
10.1186/s13321-021-00492-5
