The combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses th...
The combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses the growth of myeloma cells
About this item
Full title
Author / Creator
Nagai, Yurie , Mimura, Naoya , Rizq, Ola , Isshiki, Yusuke , Oshima, Motohiko , Rizk, Mohamed , Saraya, Atsunori , Koide, Shuhei , Nakajima-Takagi, Yaeko , Miyota, Makiko , Chiba, Tetsuhiro , Oshima-Hasegawa, Nagisa , Muto, Tomoya , Tsukamoto, Shokichi , Mitsukawa, Shio , Takeda, Yusuke , Ohwada, Chikako , Takeuchi, Masahiro , Iseki, Tohru , Nakaseko, Chiaki , Lennox, William , Sheedy, Josephine , Weetall, Marla , Yokote, Koutaro , Iwama, Atsushi and Sakaida, Emiko
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The novel small molecule PTC596 inhibits microtubule polymerization and its clinical development has been initiated for some solid cancers. We herein investigated the preclinical efficacy of PTC596 alone and in combination with proteasome inhibitors in the treatment of multiple myeloma (MM). PTC596 inhibited the proliferation of MM cell lines as we...
Alternative Titles
Full title
The combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses the growth of myeloma cells
Authors, Artists and Contributors
Author / Creator
Mimura, Naoya
Rizq, Ola
Isshiki, Yusuke
Oshima, Motohiko
Rizk, Mohamed
Saraya, Atsunori
Koide, Shuhei
Nakajima-Takagi, Yaeko
Miyota, Makiko
Chiba, Tetsuhiro
Oshima-Hasegawa, Nagisa
Muto, Tomoya
Tsukamoto, Shokichi
Mitsukawa, Shio
Takeda, Yusuke
Ohwada, Chikako
Takeuchi, Masahiro
Iseki, Tohru
Nakaseko, Chiaki
Lennox, William
Sheedy, Josephine
Weetall, Marla
Yokote, Koutaro
Iwama, Atsushi
Sakaida, Emiko
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_481913bfae7549a8909dc48c57cf66bb
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_481913bfae7549a8909dc48c57cf66bb
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-81577-x
