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Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin

Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_48c6986ca9f3427294ec05c869483932

Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin

About this item

Full title

Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2017-05, Vol.8 (1), p.15079-15079, Article 15079

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

In the cerebellar cortex, Purkinje cells (PCs) receive signals from different inputs through their extensively branched dendrites and serve as an integration centre. Defects in the dendritic development of PCs thus disrupt cerebellar circuitry and cause ataxia. Here we report that specific inactivation of both
Lhx1
and
Lhx5
in postnatal...

Alternative Titles

Full title

Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_48c6986ca9f3427294ec05c869483932

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_48c6986ca9f3427294ec05c869483932

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/ncomms15079

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