Biophysical Kv3 channel alterations dampen excitability of cortical PV interneurons and contribute t...
Biophysical Kv3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer’s
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Cambridge: eLife Sciences Publications Ltd
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English
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Cambridge: eLife Sciences Publications Ltd
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In Alzheimer’s disease (AD), a multitude of genetic risk factors and early biomarkers are known. Nevertheless, the causal factors responsible for initiating cognitive decline in AD remain controversial. Toxic plaques and tangles correlate with progressive neuropathology, yet disruptions in circuit activity emerge before their deposition in AD model...
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Biophysical Kv3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer’s
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TN_cdi_doaj_primary_oai_doaj_org_article_48d3ee7817ef4b4e91c5efc05739463b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_48d3ee7817ef4b4e91c5efc05739463b
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2050-084X
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2050-084X
DOI
10.7554/eLife.75316