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Biophysical Kv3 channel alterations dampen excitability of cortical PV interneurons and contribute t...

Biophysical Kv3 channel alterations dampen excitability of cortical PV interneurons and contribute t...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_48d3ee7817ef4b4e91c5efc05739463b

Biophysical Kv3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer’s

About this item

Full title

Biophysical Kv3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer’s

Publisher

Cambridge: eLife Sciences Publications Ltd

Journal title

eLife, 2022-06, Vol.11

Language

English

Formats

Publication information

Publisher

Cambridge: eLife Sciences Publications Ltd

More information

Scope and Contents

Contents

In Alzheimer’s disease (AD), a multitude of genetic risk factors and early biomarkers are known. Nevertheless, the causal factors responsible for initiating cognitive decline in AD remain controversial. Toxic plaques and tangles correlate with progressive neuropathology, yet disruptions in circuit activity emerge before their deposition in AD model...

Alternative Titles

Full title

Biophysical Kv3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer’s

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_48d3ee7817ef4b4e91c5efc05739463b

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_48d3ee7817ef4b4e91c5efc05739463b

Other Identifiers

ISSN

2050-084X

E-ISSN

2050-084X

DOI

10.7554/eLife.75316

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