Coevolution-based prediction of key allosteric residues for protein function regulation
Coevolution-based prediction of key allosteric residues for protein function regulation
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Publisher
England: eLife Sciences Publications, Ltd
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English
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England: eLife Sciences Publications, Ltd
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Contents
Allostery is fundamental to many biological processes. Due to the distant regulation nature, how allosteric mutations, modifications, and effector binding impact protein function is difficult to forecast. In protein engineering, remote mutations cannot be rationally designed without large-scale experimental screening. Allosteric drugs have raised m...
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Full title
Coevolution-based prediction of key allosteric residues for protein function regulation
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TN_cdi_doaj_primary_oai_doaj_org_article_494c05a4425545be8a974750e6e64884
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_494c05a4425545be8a974750e6e64884
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.81850
