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Detection of prions in matching post-mortem skin and cerebrospinal fluid samples using second-genera...

Detection of prions in matching post-mortem skin and cerebrospinal fluid samples using second-genera...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4a0a7a4517b84d01adcc462d7d759046

Detection of prions in matching post-mortem skin and cerebrospinal fluid samples using second-generation real-time quaking-induced conversion assay

About this item

Full title

Detection of prions in matching post-mortem skin and cerebrospinal fluid samples using second-generation real-time quaking-induced conversion assay

Publisher

London: Nature Publishing Group UK

Journal title

Scientific reports, 2024-03, Vol.14 (1), p.6294-6294, Article 6294

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Real-time quaking-induced conversion assay (RT-QuIC) exploits templating activity of pathogenic prion protein for ultrasensitive detection of prions. We have utilized second generation RT-QuIC assay to analyze matching
post-mortem
cerebrospinal fluid and skin samples of 38 prion disease patients and of 30 deceased neurological controls. The a...

Alternative Titles

Full title

Detection of prions in matching post-mortem skin and cerebrospinal fluid samples using second-generation real-time quaking-induced conversion assay

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_4a0a7a4517b84d01adcc462d7d759046

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4a0a7a4517b84d01adcc462d7d759046

Other Identifiers

ISSN

2045-2322

E-ISSN

2045-2322

DOI

10.1038/s41598-024-56789-6

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