Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprot...
Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines
About this item
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Author / Creator
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS) , He, Linling , Chaudhary, Anshul , Lin, Xiaohe , Sou, Cindy , Alkutkar, Tanwee , Kumar, Sonu , Ngo, Timothy , Kosviner, Ezra , Ozorowski, Gabriel , Stanfield, Robyn L. , Ward, Andrew B. , Wilson, Ian A. and Zhu, Jiang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Ebola virus (EBOV) glycoprotein (GP) can be recognized by neutralizing antibodies (NAbs) and is the main target for vaccine design. Here, we first investigate the contribution of the stalk and heptad repeat 1-C (HR1
C
) regions to GP metastability. Specific stalk and HR1
C
modifications in a mucin-deleted form (GPΔmuc) increase trimer y...
Alternative Titles
Full title
Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4a392730803043be9929af5ed1751e87
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4a392730803043be9929af5ed1751e87
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-22867-w
