Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesi...
Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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The epigenomic reader Brd4 is an important drug target for cancers. However, its role in cell differentiation and animal development remains largely unclear. Using two conditional knockout mouse strains and derived cells, we demonstrate that Brd4 controls cell identity gene induction and is essential for adipogenesis and myogenesis. Brd4 co-localiz...
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Full title
Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis
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TN_cdi_doaj_primary_oai_doaj_org_article_4a7139498fa741c093bf16e3320affb8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4a7139498fa741c093bf16e3320affb8
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02403-5
