RNA recognition by Npl3p reveals U2 snRNA-binding compatible with a chaperone role during splicing
RNA recognition by Npl3p reveals U2 snRNA-binding compatible with a chaperone role during splicing
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The conserved SR-like protein Npl3 promotes splicing of diverse pre-mRNAs. However, the RNA sequence(s) recognized by the RNA Recognition Motifs (RRM1 & RRM2) of Npl3 during the splicing reaction remain elusive. Here, we developed a split-iCRAC approach in yeast to uncover the consensus sequence bound to each RRM. High-resolution NMR structures sho...
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RNA recognition by Npl3p reveals U2 snRNA-binding compatible with a chaperone role during splicing
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TN_cdi_doaj_primary_oai_doaj_org_article_4a88fb1ca6af451d9d41da0376069163
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4a88fb1ca6af451d9d41da0376069163
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-42962-4
