The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogene...
The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability
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Author / Creator
Derrien, Jennifer , Guérin-Charbonnel, Catherine , Gaborit, Victor , Campion, Loïc , Devic, Magali , Douillard, Elise , Roi, Nathalie , Avet-Loiseau, Hervé , Decaux, Olivier , Facon, Thierry , Mallm, Jan-Philipp , Eils, Roland , Munshi, Nikhil C , Moreau, Philippe , Herrmann, Carl , Magrangeas, Florence and Minvielle, Stéphane
Publisher
England: BioMed Central
Journal title
Language
English
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Publisher
England: BioMed Central
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Scope and Contents
Contents
Cancer evolution depends on epigenetic and genetic diversity. Historically, in multiple myeloma (MM), subclonal diversity and tumor evolution have been investigated mostly from a genetic perspective.
Here, we performed an analysis of 42 MM samples from 21 patients by using enhanced reduced representation bisulfite sequencing (eRRBS). We combined...
Alternative Titles
Full title
The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability
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TN_cdi_doaj_primary_oai_doaj_org_article_4a911b1129d149468316660d33d6e2e4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4a911b1129d149468316660d33d6e2e4
Other Identifiers
ISSN
1756-994X
E-ISSN
1756-994X
DOI
10.1186/s13073-021-00938-3
