Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1...
Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype
About this item
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Author / Creator
Chen, Degao , Xie, Jing , Fiskesund, Roland , Dong, Wenqian , Liang, Xiaoyu , Lv, Jiadi , Jin, Xun , Liu, Jinyan , Mo, Siqi , Zhang, Tianzhen , Cheng, Feiran , Zhou, Yabo , Zhang, Huafeng , Tang, Ke , Ma, Jingwei , Liu, Yuying and Huang, Bo
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Resetting tumor-associated macrophages (TAMs) is a promising strategy to ameliorate the immunosuppressive tumor microenvironment and improve innate and adaptive antitumor immunity. Here we show that chloroquine (CQ), a proven anti-malarial drug, can function as an antitumor immune modulator that switches TAMs from M2 to tumor-killing M1 phenotype....
Alternative Titles
Full title
Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4a9c4b1511e545f59e2bd49d27a475dc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4a9c4b1511e545f59e2bd49d27a475dc
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-03225-9
