Cooperation of TRADD- and RIPK1-dependent cell death pathways in maintaining intestinal homeostasis
Cooperation of TRADD- and RIPK1-dependent cell death pathways in maintaining intestinal homeostasis
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Author / Creator
Sun, Ziyu , Ye, Jianyu , Sun, Weimin , Jiang, Libo , Shan, Bing , Zhang, Mengmeng , Xu, Jingyi , Li, Wanjin , Liu, Jianping , Jing, Hongyang , Zhang, Tian , Hou, Meiling , Xie, Cen , Wu, Rongling , Pan, Heling and Yuan, Junying
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Dysfunctional NF-κB signaling is critically involved in inflammatory bowel disease (IBD). We investigated the mechanism by which RIPK1 and TRADD, two key mediators of NF-κB signaling, in mediating intestinal pathology using TAK1 IEC deficient model. We show that phosphorylation of TRADD by TAK1 modulates RIPK1-dependent apoptosis. TRADD and RIPK1 a...
Alternative Titles
Full title
Cooperation of TRADD- and RIPK1-dependent cell death pathways in maintaining intestinal homeostasis
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TN_cdi_doaj_primary_oai_doaj_org_article_4abf3e9398b44938b049d449eaf3d3ad
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4abf3e9398b44938b049d449eaf3d3ad
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-57211-z
