Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils
Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Pathological aggregation of the protein tau into insoluble aggregates is a hallmark of neurodegenerative diseases. The emergence of disease-specific tau aggregate structures termed tau strains, however, remains elusive. Here we show that full-length tau protein can be aggregated in the absence of co-factors into seeding-competent amyloid fibrils th...
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Full title
Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils
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TN_cdi_doaj_primary_oai_doaj_org_article_4ae08ea82f3e4f1da86a83d9dfe205fb
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4ae08ea82f3e4f1da86a83d9dfe205fb
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-24362-8
